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- Hampton-Preston House, 1615 Blanding St., Columbia
- Lace House (Robertson House), 803 Richland St., Columbia
- South Carolina Governor’s Mansion, 800 Richland St., Columbia
- South Carolina State Hospital, Mills Building (South Carolina Lunatic Asylum), 2100 Bull St., Columbia
- Old Campus District, University of South Carolina, (University of South Carolina Historic District), Columbia
- South Carolina State House, Main & Gervais Sts., Columbia
- Ainsley Hall House (Robert Mills House), 1616 Blanding St., Columbia
- Washington Street United Methodist Church, 1401 Washington St., Columbia
- First Baptist Church, 1306 Hampton St., Columbia
- First Presbyterian Church, 1324 Marion St., Columbia
- Kensington Plantation House, off S.C. Hwy. 764, Eastover vicinity
- Trinity Episcopal Church, 1100 Sumter St., Columbia
- Millwood, U.S. Hwy. 378, Columbia vicinity
- Hale-Elmore-Seibels House (Seibels House), 1601 Richland St., Columbia
- Horry-Guignard House, 1527 Senate St., Columbia
- Chesnut Cottage, 1718 Hampton St., Columbia
- Caldwell-Hampton-Boyleston House, 829 Richland St., Columbia
- Columbia Historic District I, Columbia
- Columbia Historic District II, Columbia
- Arsenal Hill (Palmetto Iron Works and Armory), 1800 Lincoln St., Columbia
- Preston C. Lorick House, 1727 Hampton St., Columbia
- Thomas Woodrow Wilson Boyhood Home, 1705 Hampton St., Columbia
- DeBruhl-Marshall House, 1401 Laurel St., Columbia
- Sylvan Building (Central National Bank), 1500 Main St., Columbia
- Supreme Court of South Carolina Building (Old United States Post Office), Gervais & Sumter Sts., Columbia
- Mann-Simons Cottage, 1403 Richland St., Columbia
- Union Station (Atlantic Coast Line Railroad and Southern Railway Station; California Dreaming), 401 S. Main St., Columbia
- Columbia City Hall (Old United States Courthouse and Post Office), Main & Laurel Sts., Columbia
- Town Theatre, 1012 Sumter St., Columbia
- Allen University Historic District, 1530 Harden St., Columbia
- Chapelle Administration Building, Allen University, 1530 Harden St., Columbia
- Columbia Canal, E bank of the Broad & Congaree Rivers, Columbia
- National Loan and Exchange Bank Building (Barringer Building), 1338 Main St., Columbia
- Woodrow Memorial Presbyterian Church (Bishop's Memorial A.M.E. Church), 2221 Washington St., Columbia
- 1210-1214 Main Street (Capitol Cafe), Columbia
- Consolidated Building, 1326-1330 Main St., Columbia
- Dovilliers-Manning-Magoffin House, 4203 St. Clair Dr., Columbia
- W.B. Smith Whaley House (Dunbar Funeral Home), 1527 Gervais St., Columbia
- Eau Claire Town Hall and Survey Publishing Company Building, 3904 Monticello Rd., Columbia
- Ebenezer Lutheran Chapel, 1301 Richland St., Columbia
- Ensor-Keenan House, 801 Wildwood Ave., Columbia
- Heslep House, 203 Saluda Ave., Columbia
- B.B. Kirkland Seed and Distributing Company (Hinson Feed and Seed Company), 912 Lady St., Columbia
- Kress Building, 1508 Main St., Columbia
- Lever Building, 1613 Main St., Columbia
- Logan School, 815 Elmwood Ave., Columbia
- McCord House, 1431 Pendleton St., Columbia
- Alston House (McDuffie's Antiques), 1811 Gervais St., Columbia
- Moore-Mann House, 1611 Hampton St., Columbia
- United States Courthouse, 1100 Laurel St., Columbia
- Wallace-McGee House, 415 Harden St., Columbia
- Zimmerman House, 1332 Pickens St., Columbia
- Zimmerman School, 1336 Pickens St., Columbia
- Lyles-Gudmundson House, Columbia
- Confederate Printing Plant (Evans and Cogswell Company), Gervais & Huger Sts., Columbia
- Lutheran Theological Seminary Building, Beam Dormitory, 4201 Main St., Columbia
- House of Peace Synagogue (The Big Apple), Hampton & Park Sts., Columbia
- Gervais Street Bridge, over the Congaree River, Columbia
- 1722-24 Main Street (Bouchier Building), Columbia
- Canal Dime Savings Bank, 1530 Main St., Columbia
- First National Bank, 1208 Washington St., Columbia
- Palmetto Building, 1400 Main St., Columbia
- Babcock Building, South Carolina State Hospital, (New South Carolina State Asylum), Bull St., Columbia
- Bethel A.M.E. Church, 1528 Sumter St., Columbia
- 303 Saluda Avenue (John C. Heslep House), Columbia
- Columbia Mills Building (Mt. Vernon Mill; South Carolina State Museum), Gervais St. on the Congaree River
- Taylor House (Columbia Museum of Art), 1505 Senate St., Columbia
- Arcade Building, 1332 Main St., Columbia
- West Gervais Street Historic District, Columbia
- Richland Cotton Mill (Whaley's Mill), 211-221 Main St., Columbia
- Fair-Rutherford and Rutherford Houses, 1326 Gregg St., Columbia
- Wardlaw Junior High School (Wardlaw Middle School), 1003 Elmwood Ave., Columbia
- Palmetto Compress and Warehouse Company Building, 617 Devine St., Columbia
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- Chappell House, Cedar Creek vicinity (ADDRESS RESTRICTED)
- Keziah Goodwyn Hopkins Brevard House (Alwehav), Horrell Hill vicinity
- Laurelwood, Eastover vicinity (Lower Richland County)
- Magnolia (Wavering Place), Gadsden vicinity (Lower Richland)
- John Jacob Calhoun Koon Farmstead, S.C. Sec. Rd. 27, Ballentine vicinity
- George P. Hoffman House, off S.C. Sec. Rd. 54, Blythewood
- Grovewood (Weston House), S.C. Hwy. 769, Congaree (Lower Richland County)
- J.A. Byrd Mercantile Store, Main St., Eastover (Lower Richland County)
- Farmers and Merchants Bank Building (Old Eastover Post Office),
- Main St., Eastover (Lower Richland County)
- Good Hope Baptist Church, U.S. Hwy. 378, Eastover vicinity (Lower Richland County)
- Goodwill Plantation, off U.S. Hwy. 378, Eastover vicinity (Lower Richland County)
- Claudius Scott Cottage, S.C. Sec. Rd. 1182, Eastover vicinity (Lower Richland County)
- St. Thomas Protestant Episcopal Church, near jct. of U.S. Hwy. 601 & S.C. Hwy. 263, Eastover (Lower Richland County)
- John J. Kaminer House, near jct. of S.C. Hwys. 48 & 769, Gadsden (Lower Richland County)
- Oakwood (Trumble Cottage), S.C. Hwy. 48, Gadsden vicinity (Lower Richland County)
- Richland Presbyterian Church, S.C. Sec. Rd. 1313, Gadsden vicinity (Lower Richland County)
- Hopkins Graded School (Old Hopkins School), jct. of S.C. Sec. Rds. 37 & 1412, Hopkins (Lower Richland County)
- Hopkins Presbyterian Church (Hopkins Methodist Church), near jct. of S.C. Sec. Rds. 66 & 86, Hopkins (Lower Richland County)
- Barber House, off S.C. Sec. Rd. 37, Hopkins vicinity (Lower Richland County)
- Nipper Creek, 38RD18, Blythewood vicinity
- Claussen’s Bakery (Claussen's Inn), 2001-2003 Greene St., Columbia
- Benedict College Historic District, Columbia
- St. Peter’s Roman Catholic Church, 1529 Assembly St., Columbia
- Waverly Historic District, Columbia
- Greyhound Bus Depot, 1200 Blanding St., Columbia
- Elmwood Park Historic District, Columbia
- Granby Mill Village Historic District, Granby
- Modjeska Monteith Simkins House, 2025 Marion St., Columbia
- North Carolina Mutual Building, 1001, 1001 1/2 and 1003 Washington St., Columbia
- Olympia Armory, 511 Granby Ln., Columbia
- Randolph Cemetery, western terminus of Elmwood Ave., Columbia
- World War Memorial Building, 920 Sumter St., at jct. with Pendleton St., Columbia
- South Carolina Penitentiary, 1511 Williams St., Columbia
- Siloam School, 1331 Congaree Rd., Eastover vicinity (African-American Primary and Secondary School Buildings MPS)
- St. Phillip School, 4350 McCords Ferry Rd., Eastover vicinity (African-American Primary and Secondary School Buildings MPS)
- Southern Cotton Oil Company, 737 Gadsden St., Columbia
- Elmwood Cemetery, 501 Elmwood Ave., Columbia
- Sidney Park C.M.E. Church, 1114 Blanding St., Columbia
- Big Lake Cattle Mound, Hopkins vicinity (Congaree Swamp National Monument MPS)
- Brady’s Cattle Mound, Hopkins vicinity (Congaree Swamp National Monument MPS)
- Bridge Abutments, Hopkins vicinity (Congaree Swamp National Monument MPS)
- Cattle Mound #6, Hopkins vicinity (Congaree Swamp National Monument MPS)
- Cook’s Lake Cattle Mound, Hopkins vicinity (Congaree Swamp National Monument MPS)
- Cooner’s Cattle Mound, Hopkins vicinity (Congaree Swamp National Monument MPS)
- Dead River Cattle Mound, Hopkins vicinity (Congaree Swamp National Monument MPS)
- Dead River Dike, Hopkins vicinity (Congaree Swamp National Monument MPS)
- Northwest Boundary Dike, Hopkins vicinity (Congaree Swamp National Monument MPS)
- Southwest Boundary Dike, Hopkins vicinity (Congaree Swamp National Monument MPS)
- McMaster School, 1106 Pickens St., Columbia
- Bellevue Historic District, Columbia
- Curtiss-Wright Hangar (Owens Field Municipal Airport Hangar), 1400 Jim Hamilton Blvd., Columbia
- Ladson Presbyterian Church, 1720 Sumter St., Columbia
- George R. Price House, 3000 Forest Dr., Columbia
- South Carolina State Armory, 1219 Assembly St., Columbia
- Carver Theatre, 1519 Harden St., Columbia
- Old Shandon Historic District, Columbia
- University Neighborhood Historic District, Columbia
- Olympia Mill, 500 Heyward St., Columbia
- North Columbia Fire Station No. 7, 2622 N. Main St., Columbia
- Columbia Township Auditorium, 1703 Taylor St., Columbia (Segregation in Columbia, South Carolina MPS)
- Harden Street Substation, 1901 Harden St., Columbia (Segregation in Columbia, South Carolina MPS)
- A.P. Williams Funeral Home, 1808 Washington St., Columbia (Segregation in Columbia, South Carolina MPS)
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